Endocrine Abstracts

Advances in stem cell biology and thyroid development have opened up the possibility of developing tissue replacement therapy for hypothyroidism. Indeed, in this session the development from stem cells of functioning thyroid tissue in mice will be reviewed. In addition new insight into the development of this technology in human cells will also be discussed. Importantly, advances in this field may lead to new therapeutic options in congenital or post-surgical hypothyroidism.</...

Thyroid Hormone exerts key effects on metabolism via its actions on diverse cell types. Central to interpreting its actions is the ability to understand how different tissues integrate and respond to circulating thyroid hormone levels. The use of novel mouse models and metabolite profiling has allowed for a new understanding of how different tissues respond to thyroid hormone to regulate metabolic function.Partially supported by Clinical Endocrinolog...

Anthony Hollenberg, MD is Chief of the Division of Endocrinology, Diabetes and Metabolism, at Beth Israel Deaconess Medical Center, USA. He is a Professor of Medicine at Harvard Medical School. Dr Hollenberg received his MD from the University of Calgary in Canada in 1986. He completed his Internal Medicine residency in 1989 and was chief resident in Medicine in 1990–1991, both at the Beth Israel Hospital. Dr Hol...

Despite the availability of synthetic thyroid hormone for therapeutic use, a significant number of patients with hypothyroidism do not feel well on replacement doses of thyroid hormones suggesting that better individualized therapy is needed. For this reason, hypothyroidism resulting from congenital lack of functional thyrocytes, surgical tissue removal, or gland ablation, represents a particularly attractive endocrine disease target that may be conceivably cured by transplant...